Sex differences in depression revealed by large genetics study

Nature NewsCenterEN 3 min read 100% complete by Na CaiOctober 25, 2025 at 04:27 PM

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A genome-wide association study (GWAS) involving nearly 200,000 individuals with major depressive disorder (MDD), published in Nature Communications, reveals that women carry more genetic risk factors for MDD than men and have stronger links to metabolic traits. The research by Thomas et al. highlights sex-specific differences in the pathology of MDD, particularly noting higher prevalence of metabolic symptoms like weight changes among women. This study underscores the importance of sex-stratified analyses in understanding the biological underpinnings of MDD for developing more precise treatments.

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Thomas et al. 60% Nature Communications ×270% ETH Zürich 80%

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major depressive disorder 100% genetic risk variants 90% genome-wide association studies (gwass) 80% metabolic traits 70% sex differences 60% genetics study 50% women vs men 40%

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major depressive disorder genetic risk variants genome-wide association studies (gwass)metabolic traits sex differences genetics study women vs men

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