‘Gland-in-a-dish’ secretes stress hormone like the real thing

Nature NewsCenterEN 1 min read 100% complete October 25, 2025 at 04:27 PM

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Scientists have successfully developed a laboratory-grown version of the adrenal cortex, an outer part of the adrenal gland that produces essential hormones for regulating metabolism, stress, and blood pressure. This "organoid," which mimics the function of secreting cortisol, a critical stress hormone, represents a first in medical research conducted as of October 21, 2025. The lab-grown structure could potentially be used to develop treatments for adrenal gland disorders. The development highlights advancements in biological techniques and offers new avenues for studying hormonal functions and diseases related to the adrenal cortex.

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Nature ×260% cortisol 70% adrenal cortex ×280%

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adrenal cortex 100% lab-grown organoids 90% cortisol production 80% stress hormone 70% metabolism regulation 60% blood pressure control 50% adrenal gland disorders 40%

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adrenal cortex lab-grown organoids cortisol production stress hormone metabolism regulation blood pressure control adrenal gland disorders

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