MIT scientists discover hidden 3D genome loops that survive cell division

Science DailyCenterEN 5 min read 100% complete October 24, 2025 at 09:08 AM

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MIT researchers have discovered that 3D loops within the genome remain intact during cell division, contrary to previous beliefs that these structures disintegrate temporarily. Using a high-resolution genome mapping method, they found that these loops, which connect regulatory DNA elements with genes, actually strengthen as chromosomes condense for division. This discovery suggests cells can "remember" genetic interactions before division and reestablish them afterward. The study, published in Nature Structural and Molecular Biology, was led by Anders Sejr Hansen, Viraat Goel, and Edward Banigan from MIT, along with Leonid Mirny and Gerd Blobel of the University of Pennsylvania's Perelman School of Medicine.

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Anders Sejr Hansen ×2100% Viraat Goel PhD '25 100% MIT ×4100%

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3d genome loops 100% cell division 90% chromosomes 80% gene activity 70% dna loops 60% gene regulation 50% mitosis 50% genetic material 40% hi-c technique 40% genome mapping 40%

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3d genome loops cell division chromosomes gene activity dna loops gene regulation mitosis genetic material hi-c technique genome mapping

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