Studies test whether gene-editing can fix high cholesterol. For now, take your medicine

Associated Press (AP)CenterEN 4 min read 100% complete by By  LAURAN NEERGAARDFebruary 11, 2026 at 07:53 PM
Studies test whether gene-editing can fix high cholesterol. For now, take your medicine

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Scientists are exploring gene-editing as a potential one-time treatment for high cholesterol, a major risk factor for heart disease. Early research by companies like CRISPR Therapeutics focuses on "switching off" specific genes, such as ANGPTL3 and PCSK9, known to influence cholesterol levels. These genes were identified through studies of individuals with naturally low cholesterol. The goal is to offer an alternative to lifelong medication like statins, which can have side effects and adherence challenges. While promising, this research is in its early stages, with clinical trials underway to assess the safety and efficacy of these gene-editing approaches. For now, doctors recommend patients continue managing their cholesterol with existing medications.

Keywords

gene editing 100% high cholesterol 90% heart disease 80% ldl cholesterol 70% clinical trial 60% angptl3 50% statins 50% pcsk9 40% cardiovascular disease 40%

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