Rigores

Chills is a feeling of coldness occurring usually during a high fever but sometimes alone in specific people. It occurs during fever as a result of the release of cytokines and prostaglandins as part of the inflammatory response, which increases the set point for body temperature in the hypothalamus. The increased set point causes the body temperature to rise (pyrexia), but also makes the patient feel chilled until the new set point is reached. The patient will also shiver because their body pro